Neuropathy & vaccination
Nervous system & vaccination

Blumstein GI, Kreithen H.  Peripheral neuropathy following tetanus toxoid administration.JAMA. 1966 Nov 28;198(9):1030-1. No abstract available.PMID: 4288653 [PubMed - indexed for MEDLINE]

Baust W, Meyer D, Wachsmuth W.  Peripheral neuropathy after administration of tetanus toxoid.J Neurol. 1979;222(2):131-33.PMID: 93631 [PubMed - indexed for MEDLINE]

Courrier A, Stenbach G, Simonnet P, Rumilly P, Lopez D, Coquillat G, Scherer C, Chopin J.   Peripheral neuropathy following fetal bovine cell rabies vaccine.Lancet. 1986 May 31;1(8492):1273. No abstract available.PMID: 2872413 [PubMed - indexed for MEDLINE]
We treated a patient who had a demyelinating peripheral neuropathy and a central nervous system inflammatory demyelinating disease. The unusual pathologic feature of dense infiltrates of atypical macrophages was observed in many areas of the brain; otherwise the process had several features in common with either multiple sclerosis or chronic relapsing experimental allergic encephalomyelitis. The illness followed "swine-flu" inoculation; exacerbation followed pneumococcal vaccination.

Cusi MG, Bianchi S, Santini L, Donati D, Valassina M, Valensin PE, Cioe L, Mazzocchio R.   Peripheral neuropathy associated with anti-myelin basic protein antibodies in a woman vaccinated with rubella virus vaccine.J Neurovirol. 1999 Apr;5(2):209-14.PMID: 10321986 [PubMed - indexed for MEDLINE]

Ducloux M, Robin Y, Chaffaut A.  [A further case of neuropathy following rabies vaccination]Bull Soc Med Afr Noire Lang Fr. 1974;19(3):247-50. French. No abstract available.PMID: 4457252 [PubMed - indexed for MEDLINE]

Dyro FM.    Vaccination mononeuropathy. Ann Neurol. 1978 May;3(5):468. No abstract available.PMID: 215078; UI: 79081241.  

Felix JK, et al.     Isolated hypoglossal nerve paralysis following influenza vaccination. Am J Dis Child. 1976 Jan;130(1):82-3.
PMID: 174422; UI: 76109122.     
Furlow TW Jr.  Neuropathy after influenza vaccination [letter]. Lancet. 1977 Jan 29;1(8005):253-4. No abstract available.PMID: 64777; UI: 77099010.

Holliday PL, Bauer RB. Polyradiculoneuritis secondary to immunization with tetanus and diphtheria toxoids.Arch Neurol. 1983 Jan;40(1):56-7. No abstract available.PMID: 6848095 [PubMed - indexed for MEDLINE]

Hasselbacher P.   Neuropathy after influenza vaccination [letter]. Lancet. 1977 Mar 5;1(8010):551-2. No abstract available.PMID: 65654; UI: 77122811.       

Paradiso, G et al, "Multifocal Demyelinating Neuropathy after Tetanus Vaccine", Medicina (B Aires), 1990, 50 (1):52-54.

Powell HC, Mizisin AP, Wiley CA, Morey MK, Hughes RA.  Relationship of adjuvants and swine influenza vaccine to experimental neuropathy in rabbits.Acta Neuropathol (Berl). 1987;73(1):12-8.PMID: 3037840 [PubMed - indexed for MEDLINE]
Experimental neuropathy, characterized by endoneurial edema and demyelination, was induced by inoculating rabbits with a combination of Freund's complete adjuvant (FCA), gangliosides, lecithin and cholesterol. A less severe demyelinating neuropathy could be induced by treatment with FCA alone but no significant change could be elicited by injection of swine influenza vaccine (SFV) alone. When FCA was combined with gangliosides, lecithins, cholesterol and SFV, neuropathy occurred, but the changes were less severe than if these agents were used without SFV. Sera were tested for myelin basic protein (MBP) and galactocerebroside (GC) antibodies in each experimental group. Neither SFV alone nor SFV combined with Freund's complete adjuvant, gangliosides, cholesterol and lecithin evoked significant antibody titers to MBP or GC. However, rabbits inoculated with FCA, gangliosides, lecithin and cholesterol had rising titers of antibody to both MBP and GC over the 3-month experimental period. One rabbit inoculated with FCA alone had significant antibody to MBP. The findings suggest that Freund's complete adjuvant alone can induce demyelination in the peripheral nerves of rabbits and that SFV may modulate the immune response acting either as an adjuvant or suppressant in the experimental demyelinating disease.

Reinstein L, Pargament JM, Goodman JS.  Peripheral neuropathy after multiple tetanus toxoid injections. Arch Phys Med Rehabil. 1982 Jul;63(7):332-4. PMID: 6284088 [PubMed - indexed for MEDLINE]
This case documents the 14th reported patient with peripheral neuropathy following tetanus toxoid injection. A 33-year-old man developed profound mixed sensorimotor peripheral neuropathy after receiving 2 tetanus toxoid injections over a 5-month period. Periodic serial electromyographic and nerve conduction studies performed over 2 years suggested both segmental demyelination and axonal neuropathy. The patient experienced partial recovery. Analysis of this case and 13 others reported in literature indicates that in almost all cases (85%), patients had received multiple tetanus toxoid injections. Also, it appears that a prolonged interval of 14 or more days between the tetanus toxoid injection and the onset of neurological symptoms is associated with a poorer prognosis for complete recovery.

Sander D, et al.   Postvaccinal plexus neuropathy following vaccination against tick-borne encephalitis and tetanus in a competitive athlete. Clin Investig. 1994 May;72(5):399. No abstract available.PMID: 8086776; UI: 94369223.
Scholz E, et al.    [Postvaccinal neuritis following prophylactic vaccination against early-summer meningo-encephalitis]. Dtsch Med Wochenschr. 1987 Apr 3;112(14):544-6. German. PMID: 3829935; UI: 87161333.
Wilmshurst JM, Macleod MJ, Hughes E, Hughes RA.  Acute sensory neuropathy in an adolescent girl following BCG vaccination. Europ J Paediatr Neurol. 1999;3(6):277-9. PMID: 10595673 [PubMed - indexed for MEDLINE]
A 13-year-old girl developed a sensory neuropathy following bacille Calmette-Guerin (BCG) vaccination, consistent with acute inflammatory demyelinating polyradiculoneuropathy or acute sensory axonal neuropathy.