Rabies vaccines recalled
Saturday, April 3, 2004 Posted: 1:55 PM EST (1855 GMT)
(CNN) -- A vaccine maker is recalling thousands of doses of rabies
vaccine after one product lot tested positive for the live vaccine.
The doses with the live vaccine, which could give someone rabies,
were not distributed.
But Aventis Pasteur is recalling four other batches of Imovax as a
precaution, the Lyon, France-based company said Friday.
The recalled vaccine, made in Lyon, was distributed between September
23, 2003, and April 2, 2004, the company said in a statement.
Rabies vaccine is made by inactivating -- killing -- live virus.
Injections of the killed virus then stimulate the body's own immune
system to develop antibodies that would kill live virus.
That process went awry at the company's plant in Lyon, where a bulk
vaccine filter failed, said Len Lavenda, in a telephone interview
with CNN from the company's U.S. headquarters in Swiftwater,
Pennsylvania. The filter has been fixed.
The U.S. Centers for Disease Control and Prevention said the risk to
anyone who may have received the vaccine is small, but cautioned that
people who received rabies vaccine in those months should contact
their health care providers.
Two groups of people get rabies vaccine: those who have been bitten
by an animal that is rabid or suspected of being rabid, and those at
risk of being bitten -- such as veterinarians, zookeepers and people
traveling to regions where rabies is common.
Last year, in the United States, about 18,000 people at risk of being
bitten got the vaccine as a prevention and another 40,000 got it
after being bitten.
The only people who need to do something as a result of the recall
are those who received the vaccine preventively, Lavenda said. The
others, in addition to getting the vaccine, would have been given
immune globulin, which contains antibodies that kill live virus.
Aventis will pay for those people to get an injection of immune
globulin, he said.
The company is also recalling vaccines that were distributed to 18
other countries, and will be sending its customers information about
the recall on Monday, Lavenda said.
Rabies is a viral infection that is mostly associated with animals.
Humans contract it by being bitten by an infected animal, the company
Human rabies is rare in the United States: Since 1990, 39 cases have