December 2004 ? Volume 145 ? Number 6


Clinical and Laboratory Observation
Stroke after varicella vaccination

Elaine Wirrell, MD, FRCPC * [MEDLINE LOOKUP]
Michael D. Hill, MD, MSc, FRCPC [MEDLINE LOOKUP]
Taj Jadavji, MD, FRCPC, FAAP [MEDLINE LOOKUP]
Adam Kirton, MD [MEDLINE LOOKUP]
Karen Barlow, MB, ChB, MRCP [MEDLINE LOOKUP]

Two children presented with acute hemiparesis 5 days and 3 weeks following
varicella vaccination. Both showed unilateral infarction of the basal
ganglia and internal capsule, a distribution consistent with varicella
angiopathy. Both children had small patent foramen ovale (PFO), and one
child also had severe iron-deficiency anemia, which may have predisposed
the patient to this adverse effect.

From the Division of Pediatric Neurology, Alberta Children's Hospital, and
the University of Calgary, Ontario, Canada
*Reprint requests: Elaine Wirrell, MD, FRCPC, Division of Pediatric
Neurology, Alberta Childrens Hospital, 1820 Richmond Rd SW, Calgary, AB
Canada T2T 5C7.
Email address: Elaine.wirrell@calgaryhealthregion.ca (Elaine Wirrell)
Submitted April 1, 2004.
Accepted August 3, 2004.
Copyright 2004 by Elsevier Inc.
doi: 10.1016/j.jpeds.2004.08.005

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