Beneficial effect of childhood diseases Chickenpox
Cancer Med. 2016 Jun;5(6):1352-8. doi: 10.1002/cam4.682. Epub 2016 Mar 13.
History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).
Amirian ES1, Scheurer ME1, Zhou R1, Wrensch MR2, Armstrong GN1, Lachance D3, Olson SH4, Lau CC1, Claus EB5,6, Barnholtz-Sloan JS7, Il'yasova D8,9, Schildkraut J9, Ali-Osman F10, Sadetzki S11,12, Jenkins RB13, Bernstein JL4, Merrell RT14, Davis FG15, Lai R16, Shete S17, Amos CI18, Melin BS19, Bondy ML1.
Varicella zoster virus (VZV) is a neurotropic α-herpesvirus that causes chickenpox and establishes life-long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse association with glioma. The Glioma International Case-Control Study (GICC) is a large, multisite consortium with data on 4533 cases and 4171 controls collected across five countries. Here, we utilized the GICC data to confirm the previously reported associations between history of chickenpox and glioma risk in one of the largest studies to date on this topic. Using two-stage random-effects restricted maximum likelihood modeling, we found that a positive history of chickenpox was associated with a 21% lower glioma risk, adjusting for age and sex (95% confidence intervals (CI): 0.65-0.96). Furthermore, the protective effect of chickenpox was stronger for high-grade gliomas. Our study provides additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental. Future studies, including meta-analyses of the literature and investigations of the potential biological mechanism, are warranted.
© 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Brain tumor; chickenpox; glioma; shingles