Prochazkova J, Sterzl I, Kucerova H, Bartova J, Stejskal VD; The beneficial effect of amalgam replacement on health in patients with autoimmunity. Neuro Endocrinol Lett. 2004 Jun;25(3):211-8.

 Results of lymphocyte reactivity measured with MELISA indicate that in vitro reactivity after the replacement of dental amalgam decreased significantly to inorganic mercury, silver, organic mercury and lead. All 6 patients with MS showed significant improvement in health.  Out of 15 patients with systemic lupus erythematosus (SLE) 11 (73%) had improvement of health.  Out of 8 patients with autoimmune thyroiditis 6 showed significant improvement in health (75%).  5 patients undergoing amalgam replacement had atopic eczema for which other studies have found more diverse factors in autoimmunity causes.  3 out of 5 of these patients had signifcant improvement in condition (60%).   Of the patients that did not have evidence of significant improvement, most tested immune reactive to nickel and the autoimmunity measure was not improved at the end of the study.  For those whose condition was worse, the autoimmunity measure for nickel was higher at the end of the study- indicating that amalgam replacement did not resolve the source of nickel exposure.  

Mutter J, Daschner F, et al, Amalgam risk assessment with coverage of references up to 2005] , Gesundheitswesen. 2005 Mar;67(3):204-16. [Article in German](Medline)

Dental Amalgam contributes substantially to human mercury load. Mercury accumulates in some organs, particularly in the brain, where it can bind to protein more tightly than other heavy metals (e. g. lead, cadmium). The elimination half time is assumed to be up to 1 - 18 years in the brain and bones. Mercury is assumed to be one of the most toxic non-radioactive elements. There are pointers to show that mercury vapour is more neurotoxic than methyl-mercury from fish. Review of recent literature suggests that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin and mucosa alterations or non-specific symptoms and complaints. The development of Alzheimer's disease or multiple sclerosis has also been linked to low-dose mercury exposure. There may be individual genetical or acquired susceptibilities for negative effects from dental amalgam. Mercury levels in the blood, urine or other biomarkers do not reflect the mercury load in critical organs. Many studies regarding dental amalgam reveal substantial methodical flaws. Removal of dental amalgam leads to permanent improvement of various chronic complaints in a relevant number of patients in various trials. Summing up, available data suggests that dental amalgam is an unsuitable material for medical, occupational and ecological reasons.

 Documentation of mechanisms by which mercury causes MS,   and 1000s of cases of recovery after amalgam replacement