Date:  Sat, 12 Nov 2005 17:37:33 +0000

Two deaths linked to Tamiflu

Two deaths linked to Tamiflu: reports
Email Print Normal font Large font November 14, 2005

AdvertisementJapan's Health Ministry has warned the anti-flu drug Tamiflu
can induce strange behaviour leading to accidental death following the
deaths of two teenagers who took the medicine, news reports said today.

One 17-year-old Japanese high school student jumped in front of a truck in
February 2004 shortly after taking the medicine, while another younger
school student is believed to have fallen from the ninth floor of his
apartment building this February, the Mainichi newspaper and Kyodo News
agency reported.

The drug's Japanese distributor, Chugai Pharmaceutical, issued a report to
the health ministry after the first incident saying a link between taking
the drug and the odd behaviour that led to the death cannot be ruled out,
the Mainichi said.

The ministry is aware of one of the cases and is warning that taking the
drug may lead to abnormal behaviour and accidental death, Kyodo News agency
said, citing an unidentified ministry official.

While Tamiflu carries a label in Japan warning of such side effects as
"abnormal behaviour" and "hallucinations", the cases are the country's
first in which strange behaviour linked to the drug has resulted in deaths,
the Mainichi said.

Comment was being sought from Health Ministry officials.

The two people who died had taken Tamiflu to treat cases of influenza and
neither exhibited psychological problems before taking the medicine, the
Mainichi newspaper reported.

The Japanese Government announced plans earlier this month to increase its
stockpile of Tamiflu to 250 million capsules, from 150 million, over the
next five years in a precautionary measure against a global flu pandemic.

Tamiflu is one of the few drugs believed effective in treating bird flu,
which has spread from Asia to Europe. Japan hasn't reported any infections
in humans by the H5N1 virus, which has killed at least 64 people in Asia
since December 2003.

Most human cases of bird flu have been traced to direct contact with sick
birds, but health officials fear the H5N1 virus could mutate into a form
that passes easily between people, possibly triggering a deadly pandemic.