"Complete recovery after iron chelation in aplastic anemia"
They treated this kid for five years .. aggressively .. and when and
ONLY when the kid was failing DUE TO their interventions / iron
buildup .. did they finally cure the kid.
Removed the iron **totally** ..
IE: targeted the iron .. and the kid was cured.
Complete hematopoietic recovery after continuous iron chelation
therapy in a patient with severe aplastic anemia with secondary
Park SJ, Han CW
J Korean Med Sci 2008 Apr; 23(2):320-3.
A 16-yr-old male patient with hemochromatosis due to multiple packed
red blood cell transfusions was referred to our emergency center for
the treatment of severe aplastic anemia and dyspnea. He was diagnosed
with aplastic anemia at 11-yr of age. He had received continuous
transfusions because an HLA-matched marrow donor was unavailable.
Following a continuous, approximately 5-yr transfusion, he was noted
to develop hemochromatosis. He had a dilated cardiomyopathy and
required diuretics and digitalis, multiple endocrine and liver
dysfunction, generalized bleeding, and skin pigmentation. A total
volume of red blood cell transfusion before deferoxamine therapy was
about 96,000 mL. He received a regular iron chelation therapy
(continuous intravenous infusion of deferoxamine, 50 mg/kg/day for 5
days q 3-4 weeks) for approximately seven years after the onset of
multiple organ failures. His cytopenia and organ dysfunctions began
be gradually recovered since about 2002, following a 4-yr
treatment. He showed completely normal ranges of peripheral blood
counts, heart size, and liver function two years ago. He has not
received any transfusions for the last four years. This finding
suggests that a continuous deferoxamine infusion may play a role in
the immune regulation in addition to iron chelation effect.
Journal of Korean medical science
[J Korean Med Sci]
Treating aplastic anemia involves suppression of the immune system,
effect achieved by daily medicine intake, or, in more severe cases, a
bone marrow transplant, a potential cure but a risky procedure.
transplanted bone marrow replaces the failing bone marrow cells with
new ones from a matching donor. The pluripotent stem cells in the
marrow reconstitute all three blood cell lines, giving the patient a
new immune system, red blood cells, and platelets. However, besides
the risk of graft failure, there is also a risk that the newly
white blood cells may attack the rest of the body ("graft-versus-host
Medical therapy of aplastic anemia often includes a short course of
anti-thymocyte globulin (ATG) or anti-lymphocyte globulin (ALG) and
several months of treatment with cyclosporin to modulate the immune
system. Mild chemotherapy with agents such as cyclophosphamide and
vincristine may also be effective. Antibodies therapy, such as ATG,
targets T-cells, which are believed to attack the bone marrow.
Steroids are generally ineffective.
In the past, before the above treatments became available, patients
with low leukocyte counts were often confined to a sterile room or
bubble (to reduce risk of infections), as in the famed case of Ted
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