Diabetes & Vaccination citations

[HIB Vaccine can cause type 1 diabetes]
Wahlberg J, et al. Vaccinations may induce diabetes-related autoantibodies in one-year-old children. Ann N Y Acad Sci. 2003 Nov;1005:404-8.  Division of Pediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. http://www.ncbi.nlm.nih.gov/pubmed/14679101?ordinalpos=10&itool=...RVDocSum
Vaccinations have been discussed as one among many environmental candidates contributing to the immune process that later may lead to type 1 diabetes. ABIS (All Babies in Southeast Sweden) is a prospective cohort study following a nonselected birth cohort of general population. In a randomly selected sample collection from 4400 children, GADA and IA-2A have been determined at the age of 1 year. The information on vaccinations was collected from questionnaires answered by the parents and was related to beta cell autoantibodies. When studying the induction of autoantibodies using the autoantibody level of 90th percentile as cutoff level, hemophilus influenza B (HIB) vaccination appeared to be a risk factor for IA-2A [OR 5.9 (CI 1.4-24.4; p = 0.01)] and for GADA [OR 3.4 (CI 1.1-10.8; p = 0.04)] in logistic regression analyses. Furthermore, the titers of IA-2A were significantly higher (p < 0.01 in Mann-Whitney test) in those children who had got HIB vaccination. When 99th percentile was used as cutoff to identify the children at risk of type 1 diabetes, BCG vaccination was associated with increased prevalence of IA-2A (p < 0.01). We conclude that HIB vaccination may have an unspecific stimulatory polyclonal effect increasing the production of GADA and IA-2A. This might be of importance under circumstances when the beta cell-related immune response is activated by other mechanisms.  PMID: 14679101

Ehrengut W. [Diabetes mellitus from post-vaccinal encephalitis]? Dtsch Med Wochenschr. 1970 May 15;95(20):1135. German. No abstract available. PMID: 4392770; UI: 70188407.

Classen, JB, MD, "The Timing of Immunization Affects The Development of Diabetes in Rodents", Autoimmunity, 1996, 24:137-145.

Classen JB.   The diabetes epidemic and the hepatitis B vaccines. N Z Med J. 1996 Sep 27;109(1030):366. No abstract available.PMID: 8890866; UI: 97045944.

Classen JB, "Childhood immunisation and diabetes mellitus," N Z Med J, 109(1022):195 1996 May 24 [letter]

Checinska Z, et al.  [A case of diabetes insipidus after smallpox vaccination]. Przegl Lek. 1966;22(6):454-5. Polish. No abstract available.PMID: 4380398; UI: 67003063.

Hewlett (1983), EL; Roberts, CO; Wolff, J; Manclark, CR; Biphasic Effect of Pertussis Vaccine on Serum Insulin in Mice; Infection and Immunity; July 1983; p 137-144

Abstract: Administration of pertussis vaccine, consisting of whole-killed Bordetella pertussis organisms, causes hyperinsulinemia and enhanced secretion of insulin in response to a variety of secretagogues in rats and mice. In examining the time course and properties of this phenomenon, we discovered two distinct and separate effects of the bacteria on glucose and insulin levels in mice. First, a heat-stable (80C for 30 min) component causes a brief hyperinsulinemia which is measurable by 1 h. maximal at 8 h. and ends in less than 48 h. This effect appears to be due to B. pertussis endotoxin and is associated with a transient, mild hypoglycemia. Second, there is a heat-labile component of the B. pertussis organism which induces a sustained (>14 days), dose-dependent hyperinsulinemia which reaches a maximum at 5 to 7 days and has no associated hypoglycemia. The two effects are further distinguishable in the early, endotoxin-induced hyperinsulinemia exhibits the normal suppressibility by exogenous epinephrine, whereas epinephrine markedly enhances the hyperinsulinemia occurring at 7 days. These two effects of B. pertussis appear to me mediated by different mechanisms and may be important in the well-recognised reactogenicity of pertussis vaccine in humans.

Petousis-Harris H, et al.      Hepatitis B vaccination and diabetes. N Z Med J. 1999 Aug 13;112(1093):303-4. No abstract available.PMID: 10493435; UI: 99421178.

Schneider H.   [Manifestation of diabetes after smallpox vaccination]. Kinderarztl Prax. 1975 Mar;43(3):101-7. German. No abstract available.PMID: 1195568; UI: 76073372.     

Patan, "Postvaccinal Severe Diabetes Mellitus", Ter Arkh, Jul 1968, 40:117-118.

Poutasi K, " Immunisation and diabetes," N Z Med J 1996 Jul 26;109(1026):283. [letter; comment]

Polster H.    [Diabetes insipidus after small pox vaccination]. Z Arztl Fortbild (Jena). 1966 Apr 1;60(7):429-32. German. No abstract available.PMID: 5983569; UI: 68017241.
Palmar I, et al.     [Encephalopathy after vaccination against smallpox with permanent sequel--diabetes insipidus]. Vojnosanit Pregl. 1972 May;29(5):242-4. Serbo-Croatian (Roman). No abstract available.PMID: 4402923; UI: 72233718.
Pawlowski B, et al.   [Mumps vaccination and type-I diabetes]. Dtsch Med Wochenschr. 1991 Apr 19;116(16):635. German. No abstract available.PMID: 2015783; UI: 91199936.

Sinaniotis, et al, "Diabetes Mellitus after Mumps Vaccination", Arc Dis Child, 1975, 50:749.66

Other Articles Linking Diabetes to Vaccines:

Dokheel, T M, "An Epidemic of Childhood Diabetes in the United States? Evidence from ....", Diabetes Care, 1993, 16:1606-1611.

Parent ME, et al, "Bacille Calmette-Guerin vaccination and incidence of IDDM in Montreal, Canada," Diabetes Care 1997 May; 20(5):767-772.

House DV, Winter WE, "Autoimmune diabetes. The role of auto-antibody markers in the prediction and prevention of insulin-dependent diabetes mellitus," Clin Lab Med 1997 Sep; 17(3):499-545.

Zeigler, M et al , "[Autoantibodies in type 1 diabetes mellitus]" Z Arztl Fortbild (Jena). 1994 Aug; 88(7-8):561-5