Volume 28, Issue 14, 19 March 2010, Pages 2671-2673

doi:10.1016/j.vaccine.2010.01.007 | How to Cite or Link Using DOI
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Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism

Vanessa Clifforda, E-mail The Corresponding Author, Jane Wadsleyb, Bernard Jennerc and Jim P. Butterya, d, Corresponding Author Contact Information, E-mail The Corresponding Author

a Infectious Diseases Unit, Department of General Medicine & Murdoch Childrens Research Institute, Royal Children's Hospital Melbourne, Parkville, Victoria 3052, Australia

b Occupational Physician, Brigade Medical Officer, Public Health Management, St Kilda Road Medical Centre, 391 St Kilda Road, Melbourne, Victoria 3004, Australia

c Department of Paediatrics, Barwon Health, Geelong, Victoria 3220, Australia

d Infectious Diseases Unit, Monash Children's Hospital, Dept of Paediatrics, Monash University, 264, Clayton Rd, Clayton, Melbourne, Victoria 3168, Australia

Received 7 September 2009; 
revised 21 December 2009; 
accepted 6 January 2010. 
Available online 17 January 2010.


We report 3 cases of orchitis following vaccination with mumps–measles–rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.