[Vaccinate for some strains and other strains will
Sisyphus and the Conjugate
"The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in
Spain in 2001 has been followed by the emergence of invasive pneumococcal
disease caused by virulent clones of non-PCV7 serotypes."
Non-PCV7 Pneumococcal Disease Increasing in Spain
Information from Industry
Advertisement Can you reduce therapy time for cUTI and AP?
Explore this 5-day therapy's clinical success rates.
By David Douglas
NEW YORK (Reuters Health) Feb 14 - The introduction of 7-valent
pneumococcal conjugate vaccine (PCV7) in Spain in 2001 has been followed by
the emergence of invasive pneumococcal disease caused by virulent clones of
In the January 15th issue of Clinical Infectious Diseases, Dr. Carmen
Munoz-Almagro of the University of Barcelona and colleagues report their
study of the incidence of culture-proven invasive pneumococcal disease
(IPD) in children admitted to a Barcelona hospital in the pre-vaccine era
from 1997 to 2001 and in 2002 to 2004.
Between the two periods there was a 58% increase in IPD in children aged
less than 2 years. In children aged 2 to 4 years, the corresponding
increase was 135%. At clinical presentation, in children aged less than 5
years, the rate of pneumonia and empyema increased by 320%.
These increases were caused by non-PCV7 serotypes, which accounted for 38%
of infecting serotypes in the pre-vaccine era compared to 72% after vaccine
However, penicillin resistance fell from 48% to 27% over the same period.
Dr. Matthew R. Moore, co-author of an accompanying editorial, told Reuters
Health that "we applaud the work of Dr. Munoz-Almagro because it will help
Spanish health authorities to evaluate the impact of pneumococcal conjugate
vaccine in the future."
Dr. Moore of the Centers for Disease Control and Prevention in Atlanta,
Georgia, added that "an important lesson from the pneumococcal conjugate
vaccine experience in the U.S. and in other countries is that surveillance
for pneumococcal disease is critical to assessing vaccine impact."
"With time and more data from Spain and elsewhere," he concluded, "we will
gain a greater understanding of the benefits and limitations of
pneumococcal conjugate vaccine use and of the optimal methods for tracking
Clin Infect Dis 2008;46:174-182.