Hemolytic anemia & vaccines
Drugs & Hemolytic anemia citations
"Acute Autoimmune Hemolytic Anemia Following DTP Vaccination: Report of a Fatal Case and Review of the Literature"
Downes KA, Domen RE, McCarron KF, Bringelsen KA. Acute autoimmune hemolytic anemia following DTP vaccination: report of a fatal case and review of the literature.Clin Pediatr (Phila). 2001 Jun;40(6):355-8. Review. No abstract available.PMID: 11824181 [PubMed - indexed for MEDLINE]
Duval D, Giger U.Vaccine-associated immune-mediated hemolytic anemia in the dog. J Vet Intern Med. 1996 Sep-Oct;10(5):290-5. PMID: 8884713 [PubMed - indexed for MEDLINE] This study provides the first clinical evidence for a temporal relationship of vaccine-associated IMHA in the dog.
B, et al. Acute hemolytic anemia related to diphtheria-pertussis-tetanus
vaccination. Acta Paediatr Scand. 1978 May;67(3):345-50. PMID: 654911; UI: 78183820.
Three infants developed severe hemolytic anemia following the second or third diphtheria-pertussistetanus vaccination. Direct antiglobulin tests were positive, and the infant most severely affected also had reduced serum complement levels, indicating an immunological mechanism for the hemolysis. The presence of IgM on the erythrocytes from 2 of the infants could be demonstrated by antiglobulin tests or immunization experiments. Heat eluates of the erythrocytes from one of the infants contained antibodies to tetanus and diphtheria toxoids, as well as to Bordetella pertussis, suggesting that these antibodies were antigenically bound to the erythrocytes. Virus antibodies or isoagglutinins, present in the serum, were not found in the eluate. No antibodies against the vaccine components could be demonstrated in eluates of erythrocytes from control subjects. In vivo experiments showed that tetanus and diphtheria toxoids were easily bound to human erythrocytes. This finding could help explain the pathogenesis of the autohemolysis. PMID: 654911, UI: 78183820