Neurological disorders and vaccination
Nervous system disease & vaccines

Ajjan N.[Post-vaccinal hemi-convulsion hemiplegia syndrome]Ann Pediatr (Paris). 1991 Nov;38(9):642-3. French. No abstract available.PMID: 1750749 [PubMed - indexed for MEDLINE]

Allerdist, H, "Neurological Complications Following Measles Virus Vaccination. Evaluation of the Cases seen Between 1971-1977", Monatsschr Kinderheilkd, Jan 1979, 127(1): 23-28.
Allerdist, H, "Neurological Complications Following Measles Vaccination", Inter Symp, Brussels, 1978, Development Biol Std, Vol 43, 259-264.

Bondarev, VN et al, "The Changes of the Nervous System in Children After Vaccination", Pediatria, Jun 1969; 48:20-24.
Badalian, LO, "Vaccinal Lesions of the Nervous System in Children," Vop Okhr Materin Dets, Dec 1959, 13:54-59

Berg, J M, "Neurological Complications of Pertussis Immunization," Brit Med Jour, July 5,1958; p 24.

Chaleomchan W, et al. Anticardiolipin antibodies in patients with rabies vaccination induced neurological complications and other neurological diseases. J Neurol Sci. 1990 May;96(2-3):143-51. PMID: 2376746; UI: 90330972.
Dieckhofer K, et al. [See Related Articles] [Neurologic disorders following tetanus vaccination. A case report]. Med Welt. 1978 Nov 3;29(44):1710-2. German. No abstract available.PMID: 713792; UI: 79052412.

Doutlik S, et al.    [Participation of autoimmunity in post-vaccination disorders of the CNS in children]. Cesk Pediatr. 1973 Oct;28(10):543-5. Czech. No abstract available.PMID: 4148839; UI: 74065566.

Ehrengut W, "Bias in evaluating CNS complications following pertussis immunization." Acta Paediatr Jpn, 1991 Aug; 33(4):421-427.
Ehrengut W at Institute of Vaccinology and Virology, Hamburg, Germany states, "Bias in the evaluation of CNS complications following pertussis immunization are the following: 1) Notifications of post-immunization adverse events, 2) Publications by vaccine producers on the frequency of adverse reactions, 3) Comparison of permanent brain damage after DPT and DT immunization, 4) Pro-immunization, 5) Immunization associated viral encephalitis, 6) Accuracy of statistics, 7) Personal. A review of these points indicates an underestimation of CNS complications after pertussis immunization."
Ehrengut W, et al.   [Neurological complications after influenza vaccination]. MMW Munch Med Wochenschr. 1977 May 20;119(20):705-10. German. PMID: 406554; UI: 77212853    

Ehrengut W.      Central nervous system sequelae of immunization against measles, mumps, rubella and poliomyelitis. Acta Paediatr Jpn. 1990 Feb;32(1):8-11. No abstract available.PMID: 2109492; UI: 90224612.
Ehrengut, W et al, "On Convulsive Reactions Following Oral vaccination Against Polio", Klin Paediatr, May 1979, 191(3):261-270.

Ehrengut W.[BCG-induced inflammation during childhood and in pregnancy. Additionally a contribution to BCG-induced necrotising cerebral arteritis]Klin Padiatr. 1990 Sep-Oct;202(5):303-7. German.PMID: 2214588 [PubMed - indexed for MEDLINE]

Finley, K H, "Pathogenesis of Encephalitis Occurring With Vaccination, Variola and Measles, Arch Neur and Psychologist, 1938; 39:1047-1054.
Froissart, M et al, "Acute Meningoencephalitis Immediately after an Influenza Vaccination", Lille Med, Oct 1978, 23(8):548-551.

Goswamy, BM, "Neurological Complications After Smallpox Vaccination", J Ass Phys India, Jan 1969, 17:41-43.
Greco D, et al, "Case-control study on encephalopathy associated with diphtheria-tetanus immunization in Campania, Italy," Bull World Health Organ 1985;63 (5):919-925.

Heidel G, et al.     [Neurologic syndromes as atypical courses of vaccination following preventive influenza A vaccination]. Z Gesamte Hyg. 1985 Apr;31(4):218-20. German. No abstract available.PMID: 4013430; UI: 85246763.

Iakunin IuA, "[Nervous system complications in children after preventive vaccinations]," Pediatriia 1968 Nov; 47 (11):19-26. [Article in Russian]

Ivanus IA.     [On disorders of the nervous system after vaccination]. Voen Med Zh. 1968 Mar;3:67-8. Russian. No abstract available.PMID: 5702896; UI: 69082504.

Kulenkampff, M et al, "Neurological Complications of Pertussis Inoculation", Arch Dis Child, 1974, 49:46.

Lenard HG, Fest U, Scholz W.  [Complications of pertussis immunization (author transl)] Monatsschr Kinderheilkd. 1977 Jun;125(6):660-7. German. PMID: 18670 [PubMed - indexed for MEDLINE]

16 cases of neurological disease and/or death shortly after pertussis immunization are reported. Eight patients had convulsions, six with ensuing permanent defects. Severe polymyositis was observed in one case. Five infants died 12 h to 4 days after vaccination: two after acute encephalopathy and three in the form of a sudden unexpected death (SID). In two fatal cases the morphological changes in the brain corresponded to those of pertussis encephalopathy: neuronal degeneration in various parts of the cortex, especially in the region of the ammons horn, and in the cerebellum. There were no signs of inflammation. Three cases underwent forensic autopsy and death was attributed to bronchopulmonary infection. Complete neuropathological work-up was only done in one case, in which the brain was normal. The critique of episodical reports and the demand for prospective studies is appreciated. Knowledge of all possible forms of complications, however, is indispensable for future investigations. Polymyositis and SID have so far not been listed as abnormal reactions to immunization. The majority of our cases became known accidentally from hospital sheets or from discussions with collegues. For a detection of all possible cases a greater awareness of doctors for the problem of pertussis immunization appears necessary. Only another 23 cases have been reported to the health authorities of the state of Lower Saxony during the last 6 to 7 years. Of those, nine were either harmless reactions or diseases probably unrelated to vaccination. Two were cases of SID, 12 and 72 h after vaccination. It is concluded that only a minor proportion of possible complications is presently reported to the health authorities.


Kulenkampff, M et al, "Neurological Complications of Pertussis Inoculation", Arch Dis Child, 1974, 49:46.

Landrigan, PJ, Whitte, J, "Neurologic Disorders Following Live Measles-virus Vaccination", JAMA, Mar 26, 1973, v223(13):1459-1462.
Lorentz, IT, et al, "Post-Vaccinal Sensory Polyneuropathy with Myoclonus", Proc Aust Ass Neurol, 1969, 6:81-86.

Mittal HS, et al.   Brainstem encephalopathy following antirabic vaccination. A case report. J Postgrad Med. 1971 Oct;17(4):184-6. No abstract available.PMID: 4400983; UI: 72131524.

Naumova, R P, et al, "Encephalitis Developing After Vaccination without a Local Skin Reaction", Vrach Delo, Jul 1979, (7):114-115.
Nedar P R, and Warren, R J, "Reported Neurological Disorders Following Live Measles Vaccine", 1968, Ped, 41:997-1001.

Pladys P, Roussey M, Dabadie A, Betremieux P, Lefrancois C. [Post-vaccinal hemi-convulsion hemiplegia syndrome]Ann Pediatr (Paris). 1991 Nov;38(9):602-4. Review. French.PMID: 1750741 [PubMed - indexed for MEDLINE]

Pokrovskaia, Nia, et al, "Neurological Complications in Children From Smallpox Vaccination", Pediatriia, Dec 1978, (12):45-49.
Plesner AM, et al.    Neurological complications and Japanese encephalitis vaccination. Lancet. 1996 Jul 20;348(9021):202-3. No abstract available.PMID: 8684185; UI: 96295326.
Ravkina LI, et al.  [Postvaccinal encephalopathy]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1973;73(2):191-4. Russian. No abstract available.PMID: 4147549; UI: 74006550     

Ryzhova TP, et al. [See Related Articles] [Neurologic complications of APDT vaccination]. Pediatriia. 1976 Jan;(1):64-7. Russian. No abstract available.PMID: 5700; UI: 76197067.

Sackey AH, Broadhead RL.Hemiplegia after measles, mumps, and rubella vaccination.BMJ. 1993 May 1;306(6886):1169. No abstract available.PMID: 8499819 [PubMed - indexed for MEDLINE]

Selvaraj N, Moonis M, Ravin P.Hemiparesis following influenza vaccination.Postgrad Med J. 1998 Oct;74(876):633-5. No abstract available.PMID: 10211371 [PubMed - indexed for MEDLINE]

Skovrankova J, et al.   [Neurologic disorders after vaccination against measles and mumps]. Cesk Pediatr. 1992 Jun;47(6):343-5. Czech. PMID: 1525918; UI: 92405299.
Scholl R, et al.     [Neurologic disorders following influenza vaccination. A case report]. Med Welt. 1978 Nov 3;29(44):1707-9. German. No abstract available.PMID: 713791; UI: 79052411.
Schlenska GK. [See Related Articles] Unusual neurological complications following tetanus toxoid administration. J Neurol. 1977 Jul 20;215(4):299-302. No abstract available.PMID: 70523; UI: 77251623.
Schumm F.    [Letter: Neurologic complications following influenza vaccination]? Dtsch Med Wochenschr. 1976 Apr 30;101(18):720-1. German. No abstract available.PMID: 177257; UI: 76164855.
Schchelkunov, SN et al, "The Role of Viruses in the Induction of Allergic Encephalomyelitis," Dokl Akad Nauk SSSR, 1990,315(1):252-255. Shields WD, et al, "Relationship of pertussis immunization to the onset of neurologic disorders: a retrospective epidemiologic study," J Pediatr 1988 Nov; 113(5):801-805.
Scoleri G, et al.      [Neurologic complications due to anticholera vaccine]. Acta Neurol (Napoli). 1974 Sep-Oct;29(5):505-10. Italian. No abstract available.PMID: 4155916; UI: 75106159.
Strom, J, "Further Experience of Reactions, Especially of a Cerebral Nature in Conjunction with Triple Vaccination", Brit Med Jour, 1967, 4:320-323.

Trump, R C, White, T R, "Cerebellar Ataxia Presumed Due To Live Attenuated Measles Virus Vaccine," JAMA, 1967, 199:165-166.
Turnbull, H M, "Encephalomyelitis Following Vaccination", Brit Jour Exper Path, 7:181, 1926.

Viparelli U, Pannone B, Sciorio G.[30 cases of neuropsychiatric complications after anticholera vaccination].Acta Neurol (Napoli). 1974 Sep-Oct;29(5):520-33. Italian. No abstract available.PMID: 4451168; UI: 75106162

Walker AM, "Neurologic events following diphtheria- tetanus-pertussis immunization," Pediatrics 1988 Mar;81 (3):345-349.
Wilbrandt D, et al.    [Rabies vaccination and neuroparalytic postvaccinal complications. Case report]. Dtsch Gesundheitsw. 1972 Nov 16;27(46):2184-7. German. No abstract available.PMID: 4405458; UI: 73087932.
Wilson J, "Proceedings: Neurological complications of DPT inoculation in infancy," Arch Dis Child 1973 Oct; 48 (10):829-830.

Postvaccinal Encephalitis

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