Rabies vaccine adverse reactions
Arega D, Zenebe G. Peripheral neuropathy following administration of nerve tissue antirabies vaccine.Ethiop Med J. 1999 Oct;37(4):269-73.PMID: 11961878 [PubMed - indexed for MEDLINE]
Ahasan HA, Chowdhury MA, Azhar MA, Rafiqueuddin AK. Neuroparalytic complications after anti-rabies vaccine (inactivated nervous tissue vaccine)Trop Doct. 1995 Apr;25(2):94. No abstract available.PMID: 7778211 [PubMed - indexed for MEDLINE]
Arch. Neurol 35: 693, 1978. The authors describe a multiple sclerosis like illness occurring 4 years after rabies immunization. It references a paper describing similar cases presenting 2-20 years after immunization with the rabies vaccine.
EC Jr, et al. The causes of the syndromes of Landry (1859) and of Guillain, Barre and
Strohl (1916). Rev Neurol (Paris). 1987;143(8-9):571-9. PMID: 2445014; UI: 88042403.
The syndromes of Landry (1859) and of Guillain, Barre and Strohl (1916) differ clinically and pathologically, the latter a purely peripheral neuritis and the former a mixture of transverse myelitis and facial neuritis. Each can be caused by many different factors, including 1) direct infection by wild or attenuated rabies virus, 2) direct auto-sensitization by myelin antigens in the vaccine....
Assis JL.Neurological complication of antirabies vaccination in Sao Paulo, Brazil. Clinical and therapeutical aspects.J Neurol Sci. 1975 Dec;26(4):593-8.PMID: 173809 [PubMed - indexed for MEDLINE]
Britton DE, Houff SA, Eiben RM.Possible interactions between rabies vaccination and a progressive degenerative CNS disease.Arch Neurol. 1978 Oct;35(10):693. No abstract available.PMID: 29594 [PubMed - indexed for MEDLINE]
Bernard KW, Smith PW, Kader FJ, Moran MJ. Neuroparalytic illness and human diploid cell rabies vaccine. JAMA. 1982 Dec 17;248(23):3136-8. No abstract available. PMID: 7143690 [PubMed - indexed for MEDLINE]
Cremieux G et AL.[Facial diplegia with cellular albumin dissociation of the cerebrospinal fluid following rabies vaccination] Nouv Presse Med. 1977 Sep 24;6(31):2781-2. French. No abstract available. PMID: 593826 [PubMed - indexed for MEDLINE]
Cremieux G, Dor JF, Mongin M. [Peripheral facial paralysis and post-antirabies-vaccination polyneuroradiculitis (author's transl)]Acta Neurol Belg. 1978 Sep-Oct;78(5):279-300. French.PMID: 716833 [PubMed - indexed for MEDLINE]
Chakravarty A. Neurologic illness following post-exposure prophylaxis with purifiled chick embryo cell antirabiesvaccine. J Assoc Physicians India. 2001 Sep;49:927-8.PMID: 11837768 [PubMed - indexed for MEDLINE]
Chaleomchan W, et al. Anticardiolipin antibodies in patients with rabies vaccination induced neurological complications and other neurological diseases. J Neurol Sci. 1990 May;96(2-3):143-51. PMID: 2376746; UI: 90330972.
Consoloni E, Cartei MA, Ioppoli C, Fonte F. [Neuropathological complications of rabies vaccination: a case with involvement of the facial nerve]Riv Neurol. 1979 Jan-Feb;49(1):53-61. Italian. No abstract available.PMID: 451398 [PubMed - indexed for MEDLINE]
Dreesen DW, Bernard KW, Parker RA, Deutsch AJ, Brown J. Immune complex-like disease in 23 persons following a booster dose of rabies human diploid cell vaccine. Vaccine. 1986 Mar;4(1):45-9. PMID: 2938356 [PubMed - indexed for MEDLINE]
Esh JB, Cunningham JG, Wiktor TJ. Vaccine-induced rabies in four cats.J Am Vet Med Assoc. 1982 Jun 1;180(11):1336-9.PMID: 7096177 [PubMed - indexed for MEDLINE]
Felix JK, Schwartz RH, Myers GJ. Isolated hypoglossal nerve paralysis following influenza vaccination.Am J Dis Child. 1976 Jan;130(1):82-3.PMID: 174422 [PubMed - indexed for MEDLINE]
Gupta JP, Bajpai HS.Neuro-paralytic complications following antirabic vaccination. Indian J Med Sci. 1966 Apr;20(4):276-9. No abstract available. PMID: 5934920 [PubMed - indexed for MEDLINE]
Gamboa ET, Cowen D, Eggers A, Cogan P, Ganti R, Brust JC.Delayed onset of post-rabies vaccination encephalitis.Ann Neurol. 1983 Jun;13(6):676-8.PMID: 6136253 [PubMed - indexed for MEDLINE]
Hemachudha T, et al. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. N Engl J Med. 1987 Feb 12;316(7):369-74. PMID: 2433582; UI: 87115665[See Related Articles]
Harrington RB, Olin R.Incomplete transverse myelitis following rabies duck embryo vaccination.JAMA. 1971 Jun 28;216(13):2137-8. No abstract available.PMID: 5108679 [PubMed - indexed for MEDLINE]
Held JR, Lopez Adaros H.[Neurological complications after the administration of newborn mouse brain antirabies vaccine]Bol Oficina Sanit Panam. 1971 Jul;71(1):50-9. Spanish. No abstract available.PMID: 4254526 [PubMed - indexed for MEDLINE]
Harry TO, Nasidi A, Fritzell B, Akinlade HO, Nereli B, Rollin P, Sureau P, Adeiga A. Trial of economical regimens of suckling mouse brain rabies vaccine for postexposure prophylaxis in Lagos, Nigeria.Vaccine. 1989 Aug;7(4):329-32.PMID: 2815968 [PubMed - indexed for MEDLINE]
Held JR, Adaros HL. Neurological disease in man following administration of suckling mouse brain antirabies vaccine.Bull World Health Organ. 1972;46(3):321-7. No abstract available.PMID: 4339746 [PubMed - indexed for MEDLINE]
Iizuka H, Amano N, Izeki E, Sakai M, Harada K. A case of antirabies inoculation encephalitis with a long clinical course.Jpn J Psychiatry Neurol. 1993 Sep;47(3):603-8.PMID: 7905539 [PubMed - indexed for MEDLINE]
Janssen EG. [Rabies vaccination with lethal outcome]Monatsschr Kinderheilkd. 1970 Jun;118(6):379-80. German. No abstract available.PMID: 5523684 [PubMed - indexed for MEDLINE]
The author reports 4 cases of neurological complications following vaccination with cerebral-type lyophilized vaccine. The cases were observed in the Province of Poznan in the period from January to April 1984, and the patients were men aged 41 to 60 years with various clinical syndromes: Landry's ascending paralysis, polyradiculoneuritis, polyneuritis and encephalopolyradiculoneuritis. The high frequency of these complications (about 3%) might have been due to the high susceptibility of the vaccinated population, or to technical errors in the production of the vaccine leading to obtaining of a vaccine bath with a high immunoallergogenicity which could trigger off the complication in persons with individual predisposition.
Knittel T, et al. Guillain-Barre syndrome and human diploid cell rabies vaccine. Lancet. 1989 Jun 10;1(8650):1334-5. No abstract available.PMID: 2566866; UI: 89260830.
Kreiner R, et al. [Encephalitis after rabies vaccination]. Psychiatr Neurol Med Psychol (Leipz). 1971 Sep;23(9):532-6. German. No abstract available.PMID: 4403287; UI: 72258327.
Larghi OP, Varela-Diaz VM, Soto E, Imas B, Cuba-Caparo A, Fuenzalida E. Laboratory investigations on neuroparalytic accidents associated with suckling mouse brain rabies vaccine. III. -- Preservation of vaccine potency after elimination of murine brain myelin by centrifugation.Ann Microbiol (Paris). 1976 Nov-Dec;127B(4):567-72.PMID: 1023791 [PubMed - indexed for MEDLINE]
(Luby JP; Ann Intern Med, 1974 Sep) Letter: Adverse reaction to duck embryo rabies vaccine.
Lery L, Gaillard L, Delphin D. [Benign neurologic accident following anti-rabies vaccination. Unforeseen clinical and biological aspects]Arch Fr Pediatr. 1975 Jun-Jul;32(6):563-7. French.PMID: 241305 [PubMed - indexed for MEDLINE]
Mittal HS, et al. Brainstem encephalopathy following antirabic vaccination. A case report. J Postgrad Med. 1971 Oct;17(4):184-6. No abstract available.PMID: 4400983; UI: 72131524.
DK, et al. Pleomorphism of fine structure of rabies virus in human and experimental
brain. J Neurol Sci. 1986 Sep;75(2):181-93. PMID: 3760910; UI: 87010723.
Identification of the Negri bodies in the brain of an 8-year-old boy who died 8 days after a paralytic illness and 20 days after a dog bite, and who had received 9 injections of Semple's anti-rabies vaccine, provided evidence that he died of acute rabies encephalitis and not of post-vaccinal allergic encephalomyelitis. The Negri bodies in the human subject and those seen in the inoculated mouse differed in their morphological structure: the former consisted of a matrix of very fine granular material bearing larger granules or strands of higher electron-density resembling nucleic acids and representing products of host cell-virus interaction; and the latter showed better defined areas of granular matrix containing tubular, bullet-shaped and elongated forms of viral structures, and nucleocapsids or capsule-deficient cores, representing the virions, emerging from them. Fine structural examination of the patient's brain and of the inoculated mouse has provided evidence of the pleomorphism of the Negri bodies and the various stages of formation of viral material and virions in them, the animal alone showing the mature virions of rabies, and proving the infectivity of the Negri bodies of the human brain. (Emphasis added)
Nogueira YL. Adverse effect versus quality control of the Fuenzalida-Palacios antirabies vaccine.Rev Inst Med Trop Sao Paulo. 1998 Sep-Oct;40(5):295-9.PMID: 10030074 [PubMed - indexed for MEDLINE]
Okoh AE. Canine rabies in Nigeria, 1970 - 1980 reported cases in vaccinated dogs.Int J Zoonoses. 1982 Dec;9(2):118-25.PMID: 7169305 [PubMed - indexed for MEDLINE]
Okolo MI. Vaccine-induced rabies infection in rural dogs in Anambra State, Nigeria.Microbios. 1989;57(231):105-12.PMID: 2739582 [PubMed - indexed for MEDLINE]
Rubin RH; Ann Intern Med, 1973 May)Adverse reactions to duck embryo rabies vaccine. Range and incidence. (
Rebucci GG, Cattania F. [Polyradiculoneuritis of the Guillain-Barre type following vaccination against rabies and smallpox. (Presentation of 2 cases)]Riv Neurobiol. 1965 Oct-Dec;11(4):669-82. Italian. No abstract available.PMID: 5888021 [PubMed - indexed for MEDLINE]
Saraiva PA, de Assis JL, Tiriba Ada C. [Neurological complications associated with anti-rabies vaccination in Sao Paulo: therapeutic, clinical and epidemiological aspects of 59 cases]Rev Paul Med. 1972 Aug;80(2):63-70. Portuguese. No abstract available.PMID: 4671574 [PubMed - indexed for MEDLINE]
da Silveira CM, Salisbury DM, de Quadros CA.
Measles vaccination and Guillain-Barre syndrome.
Lancet. 1997 Jan 4;349(9044):14-6.PMID: 8988116 [PubMed - indexed for MEDLINE]
Schoop HD, Rohrbach P. [Progressive neurological complications after rabies immunization with Hempt vaccine]Dtsch Med Wochenschr. 1974 Sep 27;99(39):1923-6. German. No abstract available.PMID: 4420696 [PubMed - indexed for MEDLINE]
Subutay N, Isik N, Zileli T. [Neurologic complications due to a sample type of rabies vaccination]Mikrobiyol Bul. 1987 Apr;21(2):145-50. Turkish.PMID: 3447020 [PubMed - indexed for MEDLINE]
Shivanand PG, et al. Leucocyte migration inhibition test in post-antirabies vaccinal encephalitis (a preliminary communication). J Postgrad Med. 1981 Oct;27(4):222-5. PMID: 6121912; UI: 82170066.
Shaul JF, et al. Duck embryo rabies vaccine. Anaphylactic reaction following initial injection. J S C Med Assoc. 1969 Oct;65(10):359-61. No abstract available.PMID: 5272125; UI: 70285226.
Swamy HS, Vasanth A, Sasikumar. Brown-Sequard syndrome due to Semple antirabies vaccine: case report.Paraplegia. 1992 Mar;30(3):181-3. No abstract available.PMID: 1630845 [PubMed - indexed for MEDLINE]
Swaddiwuthipong W, Weniger BG, Wattanasri S, Warrell MJ. A high rate of neurological complications following Semple anti-rabies vaccine.Trans R Soc Trop Med Hyg. 1988;82(3):472-5.PMID: 2906768 [PubMed - indexed for MEDLINE]
Swamy HS, Shankar SK, Chandra PS, Aroor SR, Krishna AS, Perumal VG. Neurological complications due to beta-propiolactone (BPL)-inactivated antirabies vaccination. Clinical, electrophysiological and therapeutic aspects.J Neurol Sci. 1984 Jan;63(1):111-28.PMID: 6699651 [PubMed - indexed for MEDLINE]
Swamy HS, Anisya V, Nandi SS, Kaliaperumal VG.Neurological complications due to Semple-type antirabies vaccine. Clinical and therapeutic aspects.J Assoc Physicians India. 1991 Sep;39(9):667-9.PMID: 1667658 [PubMed - indexed for MEDLINE]
Tornatore CS, Richert JR. CNS demyelination associated with diploid cell rabies vaccine. Lancet. 1990 Jun 2;335(8701):1346-7. No abstract available. PMID: 1971408 [PubMed - indexed for MEDLINE]
Tornatore CS, Richert JR, "CNS demyelination associated with diploid cell rabies vaccine." Lancet 1990 Jun 2;335(8701):1346-1347.
Trejos A, Lewis V, Fuenzalida E, Larghi OP. Laboratory investigations of neuroparalytic accidents associated with suckling mouse brain rabies vaccine. I.--Encephalitogenicity and virological studies.Ann Immunol (Paris). 1974 Nov;125(6):917-24. No abstract available.PMID: 4157004 [PubMed - indexed for MEDLINE]
Development of neurologic complications after Semple rabies vaccine is closely linked to development of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassay in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89 and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic complication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 45-170. PMID: 1688875, UI: 90131050
Udawat H, Nayak R, Chaudhary HR, Goyal RK. Guillain-Barre syndrome following antirabies vaccine.J Assoc Physicians India. 2000 May;48(5):538-9. No abstract available.PMID: 11273154 [PubMed - indexed for MEDLINE]
Vergara I, Toro G, Roman G, Mendoza G. Fatal Guillain-Barre syndrome with reduced-dose antirabies vaccination.Arch Neurol. 1979 Apr;36(4):254. No abstract available.PMID: 426675 [PubMed - indexed for MEDLINE
Varela'Diaz VM, Imas B, Soto E, Larghi OP, Cuba-Caparo A, Fuenzalida E. Laboratory investigations on neuroparalytic accidents associated to suckling mouse brain rabies vaccine. II.--Encephalitogenicity of murine brain myelin preparations.Ann Immunol (Paris). 1974 Nov;125(6):925-38. No abstract available.PMID: 4143100 [PubMed - indexed for MEDLINE]
Varga SM, Szabo I, Balazs L. [Hyperacute encephalomyelitis following lyssa vaccination]Morphol Igazsagugyi Orv Sz. 1979 Jan;19(1):27-31. Hungarian.PMID: 34789 [PubMed - indexed for MEDLINE]
Vaidya CH, et al. Polyneuritis--a complication of antirabic vaccination. J Postgrad Med. 1970 Jul;16(3):132-4. No abstract available.PMID: 5472424; UI: 71011461
Van der Meyden CH, et al. Neurological complications of rabies vaccines. S Afr Med J. 1978 Apr 1;53(13):478. No abstract available.PMID: 27870; UI: 78228867.
D, et al. [Rabies vaccination and neuroparalytic postvaccinal
complications. Case report]. Dtsch Gesundheitsw. 1972 Nov 16;27(46):2184-7. German. No
abstract available.PMID: 4405458; UI: 73087932.
Warrell MJ, et al. Rapid diagnosis of rabies and post-vaccinal encephalitides. Clin Exp Immunol. 1988 Feb;71(2):229-34. PMID: 2894908; UI: 88165606.
Zintchenko (1965) has reported 12 patients in whom multiple sclerois first became evident after a course of anti-rabies vaccination--British Medical Journal 2:210-213, 1967.
I am a 48 yr old female and was bitten when I was about 8 yrs old...It is my understanding that the older form of rabies vaccine is the worst for causing neuro symptoms....I dont think I was ever the same afteer the vaccines (looking back everyone thought I was normal but I know now I was not . ...something was wrong with me but I had to break befor it was recognized...It started with obcessive compulsive behavior right after that(now I want you to know I am in a very emotionally balanced family...no problems..no stresses causing the symptoms) Then as I got older, I just didnt have as much energy as my peers...my legs gave out...I got fatigued so easily....was just so exausted...got weaker....just didnt feel like doing anything ....mentally I had ambition but that is as far as my ambition got....THen when I was 21, I had a host of problems related to the autonomic nervous system which no on e knew was the cause or understood......When I was 36, I literly felt like I was dying...body began to shut down and was sooooo weak..A fter going to 4 neurologist, I went to a major center and was diagnosed as having demylinating neurapathy with dysautonomia......not much they can do except treat the symptoms....as for me, I pray for a miracle and do the alternative treatment. It has been 10 yrs since my diagnosis and I am still here where as I thought Id be dead or at least in a wheel chair by now.....Let me know more about your situation...was so glad to have somone to talk to about this since it is never mentioned...Blessings to you this and all Christmas......Thanks
Has anyone ever had trouble with rabies vaccine? When I was 5yrs old (1976) I received the 23 rabie shots in my stomach for a severe facial dog bite. In 1993 I began having demyelination in my rt arm, also numb patches on all my limbs. Recent diagnosis is a immune mediated polyneurolpathy. She would like to call in CIDP but I no longer have any motor demyelination, it is all sensory related. Although I do have general progressive limb weakness in my upper extremities. ALso joint pain in my rt knee, hip, and rt thumb.
Was just wondering if anyone has any information regarding this. It would be very helpful for me. Thank you