Glutathione  Selenium  Seizures

Glutathione peroxidase deficiency and childhood seizures.

Weber GF, Maertens P, Meng XZ, Pippenger CE.
Lancet. 1991 Jun 15;337(8755):1443-4.

Source

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

Abstract

4 children with intractable seizures, repeated infections, and intolerance to anticonvulsants had evidence of glutathione peroxidase deficiency. 2 had low intracellular enzyme activity but normal blood selenium and high plasma glutathione peroxidase concentrations. The other 2 had low intracellular glutathione peroxidase activity with low circulating glutathione peroxidase and selenium concentrations. The clinical state of the children improved after discontinuation of anticonvulsant medication and selenium substitution.

Comment in

PMID:
1675321
[PubMed - indexed for MEDLINE]