BCG (Bacille Calmette-Guerin) vaccine adverse reactions
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"133 Children Contract Tuberculosis in Southern Kazakhstan"

[1997] J. A. Ratón, M.D. Disseminated Bacillus Calmette-Guerin Infection in an HIV-Infected Child: A Case with Cutaneous Lesions This is the first reported case of disseminated BCG infection in an HIV-infected child presenting with cutaneous lesions.


BCG cancer therapy:
Arrese M, Ebel L, Hofmann E, Gaete P, Jara A, Cabrera K, Araos F, Del Rio P, Valdivieso V.   [Miliary tuberculosis as a complication of BCG immunotherapy in cancer of the bladder. Case report] Rev Med Chil. 1992 Aug;120(8):910-3. Spanish. PMID: 1340967 [PubMed - indexed for MEDLINE]
Peyriere H, Klouche K, Beraud JJ, Blayac JP, Hillaire-Buys D. Fatal systemic reaction after multiple doses of intravesical bacillus Calmette-Guerin for polyposis.Ann Pharmacother. 2000 Nov;34(11):1279-82.PMID: 11098343 [PubMed - indexed for MEDLINE]
Clavel G, Grados F, Cayrolle G, Bellony R, Leduc I, Lafont B, Ducroix JP, Fardellone P.   Polyarthritis following intravesical BCG immunotherapy. Report of a case and review of 26 cases in the literature. Rev Rhum Engl Ed. 1999 Feb;66(2):115-8. Review. PMID: 10084173 [PubMed - indexed for MEDLINE]
Donaldson RC, Canaan SA Jr, McLean RB, Ackerman LV.  Uveitis and vitiligo associated with BCG treatment for malignant melanoma. Surgery. 1974 Nov;76(5):771-8. No abstract available. PMID: 4424743 [PubMed - indexed for MEDLINE]

Magnon R, et al. [See Related Articles] Disseminated cutaneous granulomas from BCG therapy. Arch Dermatol. 1980 Mar;116(3):355. No abstract available.PMID: 7369757; UI: 80174030.

Modesto A, Marty L, Suc JM, Kleinknecht D, de Fremont JF, Marsepoil T, Veyssier P.Renal complications of intravesical bacillus Calmette-Guerin therapy.Am J Nephrol. 1991;11(6):501-4. Review.PMID: 1819218 [PubMed - indexed for MEDLINE]
Price GE.  Arthritis and iritis after BCG therapy for bladder cancer. J Rheumatol. 1994 Mar;21(3):564-5. PMID: 8006904
Strausser JL, et al.           Pott's disease following BCG therapy of melanoma. Cancer. 1981 Sep 1;48(5):1154-6. PMID: 7272949; UI: 82001867.
The first reported case of a patient with BCG-induced Pott's disease following immunotherapy for melanoma is presented. No signs or symptoms of the disease were detected for 2 1/2 years after therapy. The diagnosis and treatment of this complication of melanoma therapy are discussed.
[See Related Articles]
Schult C.           [Side effects of BCG immune therapy in 511 patients with malignant melanoma]. Hautarzt. 1984 Feb;35(2):78-83. German. PMID: 6706581; UI: 84161176.
The main side-effects of BCG vaccination by scarification in 511 patients with malignant melanoma since 1974 have been fatigue and exhaustion, swelling of the lymph-nodes, influenza-like symptoms, nausea and dizziness. Only in 8 patients were the side-effects more severe, requiring the cessation of treatment in some of them. One patient developed granulomatous hepatitis, another experienced a reactivation of pulmonary tuberculosis. Allergic reactions occurred in two patients. A further patient developed recurrent erysipelas in the draining areas of the scarification. In two patients we observed continuous severe joint troubles, which were not due to metastatic disease. The eighth patient developed keloids at the vaccination sites on the upper arms. One third of the patients had no side-effects. Altogether vaccinations were tolerated well by most of the patients. Nearly all of them were able to work normally.
[See Related Articles]


Agzamov RA, et al. [See Related Articles] [Complications of BCG vaccination in young children]. Probl Tuberk. 1983 Mar;(3):14-6. Russian. No abstract available.PMID: 6856599; UI: 83221466.

Baloira Villar A, Aguero Balbin R, Bustamante Ruiz A, Jimenez Gomez A.   [Miliary tuberculosis secondary to intravesical instillation of Calmette-Guerin bacilli] Med Clin (Barc). 1992 Jun 20;99(4):158. Spanish. No abstract available. PMID: 1635417 [PubMed - indexed for MEDLINE]
Blancher G, et al. [See Related Articles] [Cervical adenitis due to BCG. Problem of vaccination by oral route]. Bull Mem Soc Med Hop Paris. 1968;119(13):1003-8. French. No abstract available.PMID: 5729342; UI: 69207644.

Chevrel G, Zech C, Miossec P. Severe uveitis followed by reactive arthritis after bacillus Calmette-Guerin therapy. J Rheumatol. 1999 Apr;26(4):1011. No abstract available. PMID: 10229442 [PubMed - indexed for MEDLINE]

Dangoisse C, et al. [See Related Articles] [Management of cutaneous complications of BCG vaccine]. Ann Dermatol Venereol. 1990;117(1):45-51. French. No abstract available.PMID: 2321900; UI: 90210480.

Ehrengut W.[BCG-induced inflammation during childhood and in pregnancy. Additionally a contribution to BCG-induced necrotising cerebral arteritis]Klin Padiatr. 1990 Sep-Oct;202(5):303-7. German.PMID: 2214588 [PubMed - indexed for MEDLINE]

Freundlich E, et al. [See Related Articles] Tuberculoid granulomata in the liver after BCG vaccination. Isr J Med Sci. 1969 Jan-Feb;5(1):108-13. No abstract available.PMID: 5796274; UI: 69240421.

Foliguet JM. [See Related Articles] [Adverse effects and complications of BCG vaccination in young adults]. Rev Corps Sante Armees Terre Mer Air. 1966 Feb;7(1):103-9. French. No abstract available.PMID: 4222336; UI: 66109151.

Foster DR.  Miliary tuberculosis following intravesical BCG treatment. Br J Radiol. 1997 Apr;70(832):429. No abstract available. PMID: 9166085 [PubMed - indexed for MEDLINE]
Foster DR.  Miliary tuberculosis: a complication of intravesical BCG treatment. Australas Radiol. 1998 May;42(2):167-8. No abstract available. PMID: 9599839 [PubMed - indexed for MEDLINE]

Gilhar A, et al. [Skin reaction to BCG vaccination]. Harefuah. 1984 Nov 1;107(9):230-1. Hebrew. No abstract available.PMID: 6526347; UI: 85128691.[See Related Articles]
Galliova J, et al. [Adverse effects of BCG vaccination]. Cesk Pediatr. 1981 Mar;36(3):155-6. Czech. No abstract available.PMID: 7226271; UI: 81186395.     

Helwig H.     [Adverse effects from BCG vaccinations]. Dtsch Med Wochenschr. 1977 May 20;102(20):774. German. No abstract available.PMID: 862528; UI: 77184669   

Hennessen W; J Biol Stand, 1977.  Observations on a BCG vaccine causing adverse reactions in newborns.

Izumi AK, et al. BCG vaccine-induced lupus vulgaris. Arch Dermatol. 1982 Mar;118(3):171-2. PMID: 7065666; UI: 82159034.[See Related Articles]
Katznelson D, et al. Polyneuritis following BCG re-vaccination. Postgrad Med J. 1982 Aug;58(682):496-7. No abstract available.PMID: 7134089; UI: 83039131.          
Kozlova AV. [See Related Articles] [Risk factors in the development of complications after BCG vaccination]. Probl Tuberk. 1984 Aug;(8):15-9. Russian. No abstract available.PMID: 6494116; UI: 85038467.
Kanwar AJ, et al.Lupus vulgaris following BCG vaccination. Int J Dermatol. 1988 Sep;27(7):525-6. No abstract available.PMID: 3220640; UI: 89122403 [See Related Articles]
Lotte A, et al. [See Related Articles] [Complications induced by BCG vaccination: retrospective study]. Bull Int Union Tuberc. 1980 Mar-Jun;55(1-2):58-67. French. No abstract available.PMID: 7214061; UI: 81161648.
Lorette G, et al. [See Related Articles] [Papular tuberculid in an infant following BCG vaccination]. Ann Dermatol Venereol. 1984;111(5):493-6. French. No abstract available.PMID: 6476730; UI: 84305600.
Lassale C, et al. [Facial lupus vulgaris caused by BCG]. Arch Fr Pediatr. 1983 Oct;40(8):643-4. French. PMID: 6651453; UI: 84078851.[See Related Articles]

Matyszak MK, Perry VH, "Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guerin." Neuroscience 1995 Feb;64(4):967-977.

Marrak H, et al.[A case of tuberculous lupus complicating BCG vaccination]. Tunis Med. 1991 Nov;69(11):651-4. French. No abstract available.PMID: 1808776; UI: 92230052.
Mitinskaia LA, et al. [See Related Articles] [Postvaccinal regional lymphadenitis in children vaccinated in the neonatal period by the BCG intradermal method]. Vopr Okhr Materin Det. 1974 Sep;19(9):50-3. Russian. No abstract available.PMID: 4471591; UI: 75034532.
Mitinskaia LA, et al. [See Related Articles] [Postvaccinal regional lymphadenitis in children vaccinated in the neonatal period by the BCG intradermal method]. Vopr Okhr Materin Det. 1974 Sep;19(9):50-3. Russian. No abstract available.PMID: 4471591; UI: 75034532.

Muller RW.  [On tuberculoses caused by BCG] Prax Pneumol. 1968 Jun;22(6):379-84. German. No abstract available.PMID: 5697911 [PubMed - indexed for MEDLINE]
Missioux D, Hermabessiere J, Sauvezie B.  Arthritis and iritis after bacillus Calmette-Guerin therapy. J Rheumatol. 1995 Oct;22(10):2010. No abstract available. PMID: 8992017 [PubMed - indexed for MEDLINE]

Nitsch K. [See Related Articles] [BCG granulomatosis]. Monatsschr Kinderheilkd. 1972 Jul;120(7):283-6. German. No abstract available.PMID: 5069826; UI: 73002587

Rao MN, et al. An unusual complication following BCG vaccination. Indian Pediatr. 1981 Feb;18(2):140-1. No abstract available.PMID: 7263010; UI: 81262939.[See Related Articles]
Raj B, et al. [See Related Articles] BCG lupus. Indian J Chest Dis Allied Sci. 1986 Apr-Jun;28(2):84-7. No abstract available.PMID: 3596660; UI: 87248909.
Ramirez O, et al. [Lupoid syndrome in "BCG-itis." Report of a case]. Med Cutan Ibero Lat Am. 1986;14(2):87-9. Spanish. PMID: 3528713; UI: 86309722.[See Related Articles]
Rodrigues A, et al. [Lupus vulgaris after BCG vaccination. A clinical case]. Med Cutan Ibero Lat Am. 1990;18(4):224-6. Portugese. PMID: 2077307; UI: 91171665.[See Related Articles]

Szczuka I. [See Related Articles] [Adverse event after BCG vaccination in Poland in the years 1994-1997]. Pneumonol Alergol Pol. 1999;67(5-6):208-16. Polish. PMID: 10570642; UI: 20037220.
Sinios A, et al. [See Related Articles] [Osteomyelitis as a sequel to BCG vaccination]. Monatsschr Kinderheilkd. 1965 Oct;113(10):605-9. German. No abstract available.PMID: 5881765; UI: 66128918.
Selimoglu MA, et al. Lupus vulgaris secondary to single BCG vaccination. A case report. Turk J Pediatr. 1998 Jul-Sep;40(3):467-71. PMID: 9763915; UI: 98436406.
Stewart EJ, et al. Lupus vulgaris-like reaction following BCG vaccination. Clin Exp Dermatol. 1996 May;21(3):232-4. No abstract available.PMID: 8914370; UI: 97071445
Urusov VA, et al. [See Related Articles] [Surgical treatment of the complications from a BCG vaccination]. Khirurgiia (Mosk). 1973 Jun;49(6):129-31. Russian. No abstract available.PMID: 4763693; UI: 74056148.
Vittori F, et al. [Tuberculosis lupus after BCG vaccination. A rare complication of the vaccination]. Arch Pediatr. 1996 May;3(5):457-9. French. PMID: 8763716; UI: 96297887.
Verbov J. Local skin complications of BCG vaccination. Practitioner. 1984 Nov;228(1397):1069-71. No abstract available.PMID: 6504810; UI: 85063414.[See Related Articles]
Vilaseca J, Guardia J, Cuxart A, Clotet B, Martinez-Vazquez JM, Bernardo L, Masana L, Garcia-Vanrell G, Bacardi R.  [Granulomatous hepatitis. Etiologic study of 107 cases (author's transl)]Med Clin (Barc). 1979 Apr 10;72(7):272-5. Spanish.PMID: 459594 [PubMed - indexed for MEDLINE]
Vollset P. [See Related Articles] [A case of anaphylactic shock following BCG vaccination]. Tidsskr Nor Laegeforen. 1965 May 15;85(10):850. Norwegian. No abstract available.PMID: 5863977; UI: 66099722.
Watkins SM. [See Related Articles] Unusual complication of B.C.G. vaccination. Br Med J. 1971 Feb 20;1(746):442. No abstract available.PMID: 5101348; UI: 71113261.
Wangoo A, et al. [See Related Articles] Bacille Calmette-Guerin (BCG)-associated inflammation and fibrosis: modulation by recombinant BCG expressing interferon-gamma (IFN-gamma). Clin Exp Immunol. 2000 Jan;119(1):92-98. [Record as supplied by publisher]PMID: 10606969.
Yen MY, et al. [See Related Articles] Bilateral optic neuritis following bacille Calmette-Guerin (BCG) vaccination. J Clin Neuroophthalmol. 1991 Dec;11(4):246-9. PMID: 1838542; UI: 92156290.
Acute sensory neuropathy in an adolescent girl following BCG vaccination. Europ J Paediatr Neurol. 1999;3(6):277-9. PMID: 10595673; UI: 20061122.
Zapasnik-Kobierska MH, et al. [See Related Articles] [Observations on lupus vulgaris after BCG vaccination]. Gruzlica. 1969 Mar;37(3):255-60. Polish. No abstract available.PMID: 5785330; UI: 69207086.
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